-          NF has been classified into three distinct types; NF1, NF2 and Schwannomatosis. They are caused by different genes, located on different chromosomes.

-          NF1 is not a rare disorder, it is the most common neurological disorder caused by a single gene.

-          NF1 is the more common form of NF, occurring in 1:3,000 births throughout the world.

-          The Neurofibromatoses are genetically-determined disorders which affect more than 100,000 Americans; this makes NF more prevalent than Cystic Fibrosis, hereditary Muscular Dystrophy, Huntington's Disease and Tay Sachs combined.

-          A person with NF has a 50-50 chance of passing NF to their child.

-          All forms of NF are autosomal dominant genetic disorders which can be inherited from a parent who has NF or may be the result of a new or "spontaneous mutation" (change) in the sperm or egg cell.

-          Each child of an affected parent has a 50% chance of inheriting the gene and developing NF.  The type of NF inherited by the child is always the same as that of the affected parent, although the severity of the manifestations may differ from person to person within a family.

-          NF is worldwide in distribution and affects both sexes equally and has no particular racial, geographic or ethnic distribution. Therefore, NF can appear in any family.

-          Although most cases of NF1 are mild to moderate, NF1 can lead to disfigurement; blindness; skeletal abnormalities; dermal, brain and spinal tumors; loss of limbs; malignancies; and learning disabilities.

-          NF1 also has a connection to developmental problems, especially learning disabilities, which are five times more common in the NF1 population than in the general population.

-          The distinguishing feature of NF2 is tumors that grow on the eighth cranial nerve in both ears, commonly causing deafness and severe balance problems.

-          NF brings on increased risk of other types of nervous system tumors as well.

-          NF can also cause severe vision problems, including cataracts, retinal abnormalities and orbital tumors. Accordingly, NF research may benefit an additional 100 million Americans (i.e. 65 million with cancer and 35 million with learning disabilities).

-          NF research began eighteen years ago by the Children's Tumor Foundation, has been enormously productive ever since.

-          The Children's Tumor Foundation (CTF) is the leading non-government initiative of research into NF.  The Foundation funds both clinical and non-clinical research to enable effective treatments and, ultimately, find a cure for NF.

-           100% of your donation will fund the Children’s Tumor Foundation's Drug Discovery initiative (DDI).  For more information, please visit: https://www.ctf.org/for-scientists/drug-discovery-initiative/